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Bacteria can induce apoptosis of the mouse macrophage through its virulent substances such as endotoxin, exotoxin, invasin etc. 细菌可通过其毒力物质如内毒素、外毒素、侵袭素等诱导小鼠巨噬细胞凋亡,是细菌逃避宿主第一道免疫防御的途径;